The effect of valsartan on left ventricular myocardial functions in hypertensive patients with left ventricular hypertrophy.

摘要

It has been shown by various diagnostic methodologies that angiotensin receptor blockage reduces left ventricular mass, improves diastolic function and increases contractility in hypertensive left ventricular hypertrophy (LVH). We planned to detect the effect of angiotensin receptor blockage on midwall mechanics and myocardial dynamics in hypertensive patients with LVH.Angiotensin 2 type 1 receptor blocker (valsartan 80-160?mg) was administered to 38 previously untreated hypertensive patients with LVH for 6 months. Left ventricular midwall mechanics and tissue Doppler velocities were measured at baseline and at the end of the study.Mean blood pressure was reduced from 152?±?14/92?±?8 to 131?±?14/83?±?9?mmHg (P?