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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer
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Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer

机译:候选生物标志物TCF21在胃癌中的蛋白表达和启动子甲基化

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摘要

Transcription factor 21 (TCF21) has been identified as a candidate tumor suppressor at 6q23-q24 that is epigenetically inactivated in many types of human cancers. This study aimed to determine the expression of TCF21 mRNA and protein in gastric cancer cell lines and tissue specimens and then investigate the prognostic impact of TCF21 expression in gastric cancer and analyze the relationship between TCF21 expression and methylation level.
机译:转录因子21(TCF21)已被确定为6q23-q24的候选肿瘤抑制因子,在许多类型的人类癌症中均被表观遗传灭活。本研究旨在确定TCF21 mRNA和蛋白在胃癌细胞系和组织标本中的表达,然后探讨TCF21表达在胃癌中的预后影响,并分析TCF21表达与甲基化水平的关系。

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