Solution structure of monomeric human FAM96A

摘要

Biological context Domain of unknown function 59 (DUF59) is a protein family found in bacteria, archaea and some eukaryotes, which is highly conserved during evolution. Members of this family from prokaryotes are reported to be involved in physiological functions such as metabolism of phenylacetic acid (Ferrandez et al. 1998; Olivera et al. 1998) and metalsulfur cluster synthesis (Lezhneva et al. 2004; Luo et al. 2012; Schwenkert et al. 2010). Three structures of bacterial DUF59s have been determined (Almeida et al. 2005) and all of them are in monomeric form.