Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens

摘要

Signaling provides the communication of living cells by processing biological information. Mammalian cells integrate information from complex intracellular signaling pathways to make decisions in response to changes in the environment. Using systematic genome-wide and pathway specific protein-protein interaction screens, a framework of the intercon-nectivity of a large number of human proteins, including therapeutically relevant disease-associated proteins has been generated by these pathways. Recent developments in these protein-protein interaction networks have increased the understanding of the mechanisms of diseases with identification of drug targets and adaptation of living cells to the environment [1-5].