Correlation of antibacterial activity of some N-(5-(2-furanyl)-2-methyl-4-oxo-4H-thieno(2,3-d)pyrimidin-3-yl)-carboxamid e and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno(2,3-d)pyrimidin-4-ones with topological indices using Hansch analysis.

摘要

The antimicrobial activity of the N-[5-(2-furanyl)-2-methyl-4-oxo-4H-theino[2,3-d]pyrimidin-3-y1]-carboxamid es and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones was correlated with different topological indices using Hansch analysis. Good correlations were obtained through a simple regression equation with third order molecular connectivity index ((3)chi). The developed QSAR models were crossvalidated by leave-one-out technique.