Accurate prediction of the unbound drug fraction in assay medium from the unbound drug fraction in plasma

Niwa-Sakai Michiko; Jinno Norimasa; Takashima Tadayuki; Ohashi Shigeki; Tagashira Mizuka; Tsurui Kazuyuki

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Accurate prediction of the unbound drug fraction in assay medium from the unbound drug fraction in plasma

机译：从血浆中的未结合药物组分准确预测测定介质中的未结合药物组分

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来源
《Drug Metabolism Reviews》 |2016年第4期|共1页
作者
Niwa-Sakai Michiko; Jinno Norimasa; Takashima Tadayuki; Ohashi Shigeki; Tagashira Mizuka; Tsurui Kazuyuki;
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正文语种 eng
中图分类药理学;
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专利

1. Accurate prediction of the unbound drug fraction in assay medium from the unbound drug fraction in plasma [J] . Niwa-Sakai Michiko, Jinno Norimasa, Takashima Tadayuki, Drug Metabolism Reviews . 2016,第1a4期

机译：从血浆中的未结合药物组分准确预测测定介质中的未结合药物组分
2. Evaluation of hepatic clearance prediction using in vitro data: Emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs [J] . HallifaxD., HoustonJ.B. Journal of pharmaceutical sciences. . 2012,第8期

机译：使用体外数据评估肝清除率预测：使用107种药物的数据库强调血浆中未结合的部分和药物电离
3. In silico prediction of brain exposure: drug free fraction, unbound brain to plasma concentration ratio and equilibrium half-life. [J] . Morena Spreafico, Matthew P Jacobson Current topics in medicinal chemistry . 2013,第7期

机译：在计算机模拟中对大脑暴露的预测：无药物分数，未结合的大脑与血浆的浓度比和平衡半衰期。
4. Further Efforts Towards Accurately Determining Unbound Fractions for Highly Plasma Protein-Bound Compounds by LC-MS [C] . Erin Frances Mulrooney, Inhou Chu, Haiping Wang, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：进一步努力通过LC-MS准确地确定高血浆蛋白质结合化合物的未结合级分
5. In situ characterization of free drug fractions and drug polymer binding in vitro using pulsatile microdialysis. [D] . Vejani, Charchil S. 2015

机译：使用脉动微透析在体外对游离药物部分和药物聚合物结合进行原位表征。
6. In silico prediction of brain exposure: drug free fraction unbound brain to plasma concentration ratio and equilibrium half-life [O] . Morena Spreafico, Matthew P. Jacobson -1

机译：在脑暴露的硅预测中：无药物分数未结合的脑对血浆浓度比和平衡半衰期
7. Correction: Applying Linear and Non-Linear Methods for Parallel Prediction of Volume of Distribution and Fraction of Unbound Drug. [O] . Eva M Del Amo, Leo Ghemtio, Henri Xhaard, 2015

机译：校正：应用线性和非线性方法平行预测未结合药物的分布和分数。

Accurate prediction of the unbound drug fraction in assay medium from the unbound drug fraction in plasma

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