Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.

Samantha J Richardson; April Bai; Ashutosh A Kulkarni; Mehran F Moghaddam

首页> 外文期刊>Drug metabolism letters >Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.

【24h】

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.

机译：药物发现效率：肝S9馏分测定作为代谢稳定性的筛选。

获取原文

获取原文并翻译 | 示例

获取外文期刊封面封底 >>

开具论文收录证明 >>

文献代查 >>

团队文献服务 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In our opinion, replacing liver microsome and hepatocyte assays with S9 assay for high throughput metabolic screening purposes provides the combined benefit of comprehensive and high quality data at a reasonable expense for drug discovery programs.

机译：我们认为，用S9分析代替肝微粒体和肝细胞分析以进行高通量代谢筛查的目的是为药物发现计划提供合理费用的综合和高质量数据的共同好处。

著录项

来源
《Drug metabolism letters 》 |2016年第2期| 共8页
作者
Samantha J Richardson; April Bai; Ashutosh A Kulkarni; Mehran F Moghaddam;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学 ;
关键词

相似文献

外文文献
中文文献
专利

1. Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability. [J] . Samantha J Richardson, April Bai, Ashutosh A Kulkarni, Drug metabolism letters . 2016 ,第2期

机译：药物发现效率：肝S9馏分测定作为代谢稳定性的筛选。
2. Use of human liver and EpiSkin (TM) S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals [J] . Journal of applied toxicology . 2020 ,第3a4期

机译：使用人肝和EPISKIN（TM）S9亚细胞分数作为筛选测定，以比较47个化妆品相关化学品的体外肝和皮肤代谢
3. A high content screening assay to predict human drug-induced liver injury during drug discovery [J] . PerssonM., L?yeA.F., MowT., Journal of Pharmacological and Toxicological Methods . 2013 ,第3期

机译：高含量筛选试验可预测药物发现过程中人为药物引起的肝损伤
4. Proteomic characterization of ocular S9 fractions for biotransformation studies in ophthalmic drug discovery [C] . Joshua L. Johnson, Jennifer L. Bushee, Upendra A. Argikar, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：眼科对药物发现中生物转化研究的眼部S9分数蛋白质组学特征
5. Engineering new tools for targeted drug discovery: Design and development of soluble, screenable mimics for challenging proteins [D] . Audu, Christopher O. 2013

机译：设计用于靶向药物发现的新工具：设计和开发具有挑战性的蛋白质的可溶性可筛选模拟物
6. Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability [O] . Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni, -1

机译：药物发现的效率：肝S9分数测定作为代谢稳定性的筛选
7. Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability [O] . Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni, 2016

机译：药物发现的效率：肝脏S9分数测定作为代谢稳定性的筛选
8. Results of an Ames Test Conducted in Salmonella Typhimurium Tester Strain TA98 in the Presence of S9 (Aroclorinduced Rat Liver S9) Metabolic Activation with Mixture of Substituted Nitrogen-Containing Heterocyclic Compounds. [R] . 2009

机译：在存在s9（aroclor诱导的大鼠肝s9）代谢活化的鼠伤寒沙门氏菌测试菌株Ta98中进行的ames试验的结果，其中含有取代的含氮杂环化合物的混合物。

Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability.

摘要

著录项

相似文献

相关主题

期刊订阅