Adipose tissue remodeling and chronic inflammation in obesity visualized by in vivo molecular imaging method

摘要

Obese visceral adipose tissue remodeling and dysfunction, based on chronic inflammation and local immunological changes, play major roles in the metabolic syndrome. Therefore, an in vivo visualization technique has been developed to assess the dynamic interplay between multiple cell types in obese adipose. In vivo imaging revealed close spatial and temporal interrelation-ships between angiogenesis and adipogenesis, which were augmented in obese adipose tissue. In addition, increased leukocyte–platelet–endothelial cell interactions were observed in the microcirculation, a hallmark of inflammation. Upregulated expression of adhesion mole-cules contribute to the local activation of inflammatory processes. We also found that large numbers of CD8+ effector T cells infiltrated into the obese adipose tissue, playing major roles in inflammatory macrophage infiltration into obese adipose tissue, the induction and maintenance of inflammation, and systemic insulin resistance.