Microspheres from Poly(D,L-lactide)/Poly(1,5-dioxepan-2-one)Miscible Blends for Controlled Drug Delivery

摘要

Novel biodegradable microspheres were designed from blends of poly(D,L-lactide)(PDLLA) and poly(1,5-dioxepan-2-one)(PDXO).The addition of PDXO to PDLLA yielded a more pliable and versatile matrix,where the properties can be controlled by means of composition.The components were fully miscible and formed homogeneous,amorphous,smooth and dense microspheres.Blend composition was a vital factor in determining the blend properties,morphology and in vitro degradation.Diclofenac sodium,a non-steroidal anti-inflammatory drug,was incorporated into PDLLA-PDXO microspheres of various composition ratios.Sustained release of drug was ob-tained.The degradation and release rates of PDLLA-PDXO microspheres were dependent on the blend composition,providing a powerful means of controlling drug delivery.