Alfred Werner Lectures-'Fine-tuning' of biomimetic siderophore analogs to optimize biological activity

摘要

A misfit in receptor-substrate recognition is easily identified by observing alteration in the microbial growth and proliferation, compared to growth characteristics of the natural counterpart. Since the sensitivity of these interactions is generally very high, minor structural changes in the substrate, induce dramatic effects ranging from low activity to the lack of it all together.