Metals in medicine: metal-related diseases-Synthesis, purification, and characterization of asymmetric Pt(IV) complexes that inhibit the Stat3 signal transduction pathway

摘要

The asymmetric Pt(IV) complex, fac-[PtCl_3(NH_3)_2(NO_2)] (CPA-7, Figure 1), has been shown to control tumor cell growth by inhibiting the Stat3 signal transduction pathway [1]. Although an improved synthesis of CPA-7 was reported by Littlefield et al. [2], uncertainty as to the exact nature of the reaction product(s) and the lack of the essential details of its purification and purity warrant a reinvestigation of this system.