New methods and tools for bioinorganic chemistry-Avoiding slips in the determination of uncaging quantum yields of organic and organometallic bio-active compounds

摘要

Protecting groups, which are cleavable by light irradiation, can be used to inactivate bio-active compounds. Upon irradiation the compounds are re-activated ("uncaged"), thereby triggering their biological function. This principle has been extensively used in chemical biology to study the spatio-temporal responses of a system to the presence of a chemical stimulus [1].