Metal–nucleic acid interactions-A metal-mediated base pair with a triazole-based tridentate ligand

摘要

The incorporation of artificial base pairs into nucleic acid double helices is a convenient method for the site-specific functionalization of these self-assembling biomolecules with metal ions [1]. We have established various nucleic acid systems with metal-mediated base pairs derived from azole ligands [2, 3]. Moreover, we recently developed a metal-mediated base pair with a trigonal planar coordination geometry of the central transition metal ion. This geometry was achieved by combining one bidentate and one monodentate ligand [4]. The triazole-based ligand used in that context was the first of an entire family of "click" nucleosides [5]. The latest addition to this family is a metal-mediated base pair with a triazole-based tridentate ligand and a complementary monodentate nucleoside. The synthesis of the new artificial nucleoside and the metal-binding properties of oligonucleotides containing the respective base pair will be reported.