Autism symptoms in Attention-Deficit/Hyperactivity Disorder:A Familial trait which Correlates with Conduct, OppositionalDefiant, Language and Motor Disorders

摘要

It is hypothesised that autism symptoms arepresent in Attention-Deficit/Hyperactivity Disorder(ADHD), are familial and index subtypes of ADHD. Aut-ism symptoms were compared in 821 ADHD probands,1050 siblings and 149 controls. Shared familiality of aut-ism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings thanmale controls. Autism symptoms were familial, partlyshared with familiality of ADHD in males. Latent classanalysis using SCQ-score yielded five classes; Class1(31%) had few autism symptoms and low comorbidity;Classes 2-4 were intermediate; Class 5(7%) had highautism symptoms and comorbidity. Thus autism symptoms.