Pitavastatin Decreases Plasma Prej81-HDL Concentration and Might Promote its Disappearance Rate in Hypercholesterolemic Patients

摘要

Aim: Pre beta 1-HDL is involved in the initial step of cholesterol efflux from peripheral cells and plays an important role in reverse cholesterol transport. We studied the effect of pitavastatin on the HDL subtraction profile, pre/?l-HDL concentration and its disappearance rate.Methods: Twenty-nine hypercholesterolemic patients were treated with pitavastatin at 2 mg/day for 4 weeks, and plasma levels of total cholesterol (TC), triglyceride, HDL-cholesterol (C), HDL2-C, HDL3-C, prebeta l-HDL, LCAT activity, and CETP mass were assayed. The prebetal-HDL disappearance rate was determined as the difference in prebeta1-HDL concentration before and after incubation at 37 癈 for 90 min divided by the pre-incubation prebeta1-HDL concentration.Results: Pitavastatin led to significant decreases in TC by 26.9% and LDL-C by 39.8%. HDL-C and HDL2-C increased significantly by 6.0% and 9.0%, respectively, but there was no significant change in HDL3-C. Prebeta1 -HDL concentration significantly decreased (-8.7%;p<0.05); however, its disappearance rate significantly increased (13.0%; p<0.05). There were significant decreases in both LCAT activity and CETP mass.Conclusion: Although pitavastatin decreased plasma prebetal-HDL concentration, it increased the prebetal-HDL disappearance rate. These data suggest that pitavastatin might promote the early step of reverse cholesterol transport.