Computer modelling of the chemical speciation of lanthanide and actinide elements in the human gastrointestinal tract

摘要

Joint Expert Speciation System (JESS) computer modelling is used to produce biokinetic models of the gastrointestinal tract, for the radiation dose from internally deposited radionuclides to be calculated. Preliminary estimations of the interactions of Gd and Cm with all the metal binding species present in the small intestine, i.e. bile and pancreatic fluid, over a pH range of pH 5.0-9.0, have been made. The development of the models and these initial validation results for the use of Gd as a surrogate for Cm, will be presented and discussed. From these aqueous studies it appears that the use of Gd as a surrogate for Cm in bile or pancreatic fluid is doubtful. However, further speciation modelling, incorporating solids, is in process to confirm these findings. (C) 1998 Published by Elsevier Science S.A. [References: 4]