首页> 外文期刊>Journal of assisted reproduction and genetics >Revisiting Germinal Vesicle Transfer as a Treatment for Aneuploidy in Infertile Women with Diminished Ovarian Reserve
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Revisiting Germinal Vesicle Transfer as a Treatment for Aneuploidy in Infertile Women with Diminished Ovarian Reserve

机译:回顾生殖囊的转移作为不育妇女卵巢储备减少的非整倍性治疗。

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The maturation and meiotic competence of human oocyte requires both healthy cytoplasmic and nuclear compartments. Germinal vesicle (GV) transfer techniques have represented useful tools for studying the interaction between the nucleus and the cytoplasm in oocyte maturation process in mammals. This report summarizes an update on the recent findings on GV transfer pertaining to improving meiotic resumption and ability of immature oocytes to mature. It also addresses mitochondrial DNA heteroplasmy as a challenge in GV transfer technology. Altogether, data to date indicate that GV transfer could improve the quality of human oocytes especially in women with advanced maternal age who usually have high rates of spindle abnormality and chromosomal misalignment. Although experimental, this technique represents a viable therapeutic option for women with diminished ovarian reserve who do not produce mature oocytes or good embryos during IVF treatment.
机译:人类卵母细胞的成熟和减数分裂能力需要健康的细胞质和核区室。生殖小泡(GV)转移技术已成为研究哺乳动物卵母细胞成熟过程中细胞核与细胞质之间相互作用的有用工具。该报告总结了有关GV转移的最新发现的最新进展,这些发现与改善减数分裂的恢复和未成熟卵母细胞的成熟能力有关。它也解决了线粒体DNA异质性问题,这是GV转移技术面临的挑战。总而言之,迄今为止的数据表明,GV转移可以改善人卵母细胞的质量,特别是在高产妇年龄的妇女中,这些妇女通常发生纺锤体异常和染色体错位的比率很高。尽管是实验性的,但该技术对于卵巢储备减少,在IVF治疗期间不产生成熟卵母细胞或良好胚胎的女性代表了可行的治疗选择。

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