Multiblock copolymers based on segments of poly (D,L-lactic-glycolic acid) and poly(ethylene glycol) or poly(epsilon-caprolactone): A comparison of their thermal properties and degradation behavior

摘要

A comparison of the thermal properties of two classes of poly(D,L-lactic-glycolic acid) multiblock copolymers is reported. In particular, the results of differential scanning calorimetry, and thermogravimetric analysis of copolymers containing poly(ethylene glycol) (PEG) or diol-terminated poly(epsilon-caprolactone) (PCDT) segments are described. The influence of the chemical structure and the length of PEG and PCDT on thermal stability, degree of crystallinity and glass transition temperature (T-g) is discussed. Finally, an evaluation of the hydrolytic behavior in conditions mimicking the physiological environment is reported. (C) 2000 John Wiley & Sons, Inc. [References: 31]