Biocidal Polymers Active by Contact. V. Synthesis of Polysiloxanes with Biocidal Activity

摘要

Polysiloxanes with 3-(alkyldimethylammonio) propyl pendant groups were synthesized by quaternaization of n-octyldimethylamine or n-dodecyldimethylamine with linear polysiloxanes containing 3-chloropropyl groups and/or 3-bromopropyl groups attached to silicon atoms. The precursor polysiloxanes, poly[(3-chloropropyl)-methylsiloxane]homopolymer and various copolymers containing (3-halogenopropyl)-methylsiloxane and dimethylsiloxane units, were obtained by equilibrium cationic polymerization of linear and cyclic silocanes with (3-halogenopropyl)methylsiloxane units. The polysiloxanes bearing quaternary ammonium salts (QSA) showed bactericidal activity against bacteria such as Escherichia coli and Aeromonas hydrophila when incorporated in a polysiloxane network. The activity was retained after 66 days of immersion in water. The QAS-containing polysiloxanes are also active in aqueous solution.