Simultaneous screening and target analytical approach by gas chromatography-quadrupole-mass spectrometry for pesticide residues in fruits and vegetables.

摘要

A full-scan GC/quadrupole/MS method was developed to perform large-scale screenings of pesticides and simultaneous quantification of 95 target compounds in a single run of 21 min. The screening method was performed by using a deconvolution of the spectrum of the full-scan data files acquired under a retention time locked method. The identification performance of the screening method was evaluated in 8 different food matrixes at 3 different concn. The system was equipped with a programmable temp. vaporizing inlet, allowing 10 mul injections. The LOQ in the full-scan mode and linearity were studied for 4 different matrixes. Correlation coeff. >0.99 were achieved in all cases, and the LOD was <20 mug/kg for 80% of the studied pesticides. Maintenance of the system was reduced by the use of a QuickSwap device that provided backflush capabilities by reversing column flow immediately after elution of the last compound of interest. The combined screening and target method was used in the analysis of >100 food samples, including a carrot sample from the European Proficiency Test FV 10, with good results.