Structure and cytotoxicity of dehydrotomatine, a minor component of tomato glycoalkaloids.

摘要

From interpretation of the FAB-MS, UV and NMR spectra, the structure of dehydrotomatine was determined as (3beta,22beta,25S)-spirosol-5-en-3-yl-O-beta-D-glucopyranosyl-(12)-O-[beta-D-xylopyranosyl-(13)]-O-beta-D-glucopyranosyl-(14)-beta-D-galactopyranoside. Dehydrotomatine exhibited cytotoxicity on animal cell lines HepG2, NIH/3T3, and U937; it was less cytotoxic than tomatine, the major tomato glycoalkaloid.