Mesenchymal Stem Cell-Derived IL-10 and Recovery From Infarction: A Third Pitch for the Chord

摘要

Mesenchymal stem cells (MSCs) are multipotent cells found in several adult tissues that are capable of differentiating into a number of different mesenchymal tissues, including muscle, bone, adipose tissue, cardiac myocytes,and neural precursors. When transplanted into allogeneictissues, these cells may persist for long periods of time, suggesting that they can evade immune surveillance and contribute to the repair of damaged tissues. Unfractionated or minimally refined bone marrow cell preparations, which probably contain a mixture of hematopoeitic, mesenchymal, and endothelial precursor cells in addition to dendritic cells, can reduce myocardial infarct size and improve performance after infarction, both in rodent models and in human clinical trials, although the exact extent to which these cells form new cardiac myocytes and promote long-term improvement in functional capacity is still hotly debated.