Stripping voltammetric determination of nicardipine using beta-cyclodextrin incorporated carbon nanotube-modified glassy carbon electrode

摘要

An electrochemical sensor modified with multi-walled carbon nanotubes-beta-cyclodextrin (MWCNTs-beta-CD) film was constructed and applied to the determination of nicardipine. The electrochemical behavior of nicardipine at the chemically modified electrode was investigated. After stripping of nicardipine on MWCNTs-beta-CD film at -0.9 V for 1 min, a well defined oxidation peak was produced in 0.04 M NaOH. Determination of nicardipine has been further improved by the formation of inclusion complex of beta-CD with nicardipine. The MWCNTs-beta-CD film showed preferable analytical characteristics in electrocatalytic oxidation for nicardipine compared with the MWCNTs film and bare glassy carbon electrode (GCE). The surface morphology of MWCNTs-beta-CD film was characterized by using electrochemical impedance spectroscopy. The calibration curve was linear from 1.0 x 10(-7) to 2.0 x 10(-5) M. The limit of detection was obtained as 1 x 10(-8) M. The results demonstrated that this electrochemical sensor has excellent sensitivity and selectivity. The sensor was applied for determination of nicardipine in blood serum with excellent recoveries.