The Effect of Beef Peptide on Blood Pressure and Serum Lipid Concentration of Spontaneously Hypertensive Rat(SHR)

摘要

The purpose of this work was to examine the effect of pcplide on blood pressure and serum lipid concentration of spontaneously, hypertensive rat(SHR). This pcptide was extracted from beef muscle hvdrolysates and identified as hexapeptide, V-L-A-Q-Y-K. This peptide showed angiotensin converting enzyme(ACE) inhibition activity in vitro experimentationIC_(50):138.34ug/ml). Diets containing 0.2g, 0.5g, and 1.0g of the peptide per kg body weight were fed to SHR every day for 8 weeks while the control group was ted on a diet and 1ml of drinking water instead of the peptide. Total cholesterol and LDL-cholesterol concentrations of the treatment groups were lower than those of the control diet feeding group. The significant suppression of systolic blood pressure was shown by increasing the concentration of peptide supplement, especially by 3 weeks of feeding, although it started fluctuating later. These results suggest that the peptide may benefieially affect blood pressure in spontaneously hypertensive rat by the 3-week administration.