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首页> 外文期刊>Journal of Animal Science >Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle.
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Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle.

机译：牛脂肪酸合酶，硬脂酰辅酶A去饱和酶，固醇调节元素结合蛋白1和生长激素基因多态性对日本黑牛脂肪酸组成和car体性状的影响。

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摘要

The quality of fat is an important factor in defining the quality of meat. Fat quality is determined by the composition of fatty acids. Among lipid metabolism-related genes, including fatty acid synthesis genes, several genetic variations have been reported in the bovine fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), sterol regulatory element-binding protein 1 (SREBP1), and GH genes. In the present study, we evaluated the single and epistatic effects of 5 genetic variations (4 SNP and 1 insertion/deletion) in 4 genes (FASN, SCD, SREBP1, and GH) on the fatty acid composition of the longissimus thoracis muscle and carcass and meat quality traits in 480 commercial Japanese Black cattle. Significant single effects of FASN, SCD, and GHL127V polymorphisms on the fatty acid composition of the longissimus thoracis muscle were detected. The A293V polymorphism of SCD had the largest effect on myristic acid (C14:0, P < 0.001), myristoleic acid (C14:1, P < 0.001), stearic acid (C18:0, P < 0.001), oleic acid (C18:1, P < 0.001), and MUFA (P < 0.001). Polymorphisms in the FASN, SCD, and SREBP1 genes showed no effect on any meat yield trait. There were no significant epistatic effects on fatty acid composition among pairs of the 3 genes (FASN, SCD, and SREBP1) involved in fatty acid synthesis. No epistatic interactions (P > 0.1) were detected between FASN and SCD for any carcass trait. When the genotypes of 3 markers (FASN, SCD, and GHL127V) were substituted from the lesser effect allele to the greater effect allele, the proportion of C18:1 increased by 4.46%. More than 20% of the genetic variance in the C18:1 level could be accounted for by these 3 genetic markers. The present results revealed that polymorphisms in 2 fatty acid synthesis genes (FASN and SCD) independently influenced fatty acid composition in the longissimus thoracis muscle. These results suggest that SNP in the FASN and SCD genes are useful markers for the improvement of fatty acid composition in commercial Japanese Black cattle.
机译：脂肪的质量是决定肉质的重要因素。脂肪质量取决于脂肪酸的组成。在脂代谢相关的基因（包括脂肪酸合成基因）中，牛脂肪酸合酶（ FASN ），硬脂酰辅酶A去饱和酶（ SCD ）报道了数种遗传变异，固醇调节元件结合蛋白1（ SREBP1 ）和 GH 基因。在本研究中，我们评估了4个基因（ FASN ， SCD ，）中5个遗传变异（4个SNP和1个插入/缺失）的单一和上位作用SREBP1 和 GH ）对480头日本黑牛的胸最长肌和car体脂肪酸组成和肉质性状的影响。检测到 FASN ， SCD 和 GHL127V 多态性对胸最长肌肌肉脂肪酸组成的显着影响。 SCD 的A293V多态性对肉豆蔻酸（C14：0， P <0.001），肉豆蔻酸（C14：1， P 的影响最大> <0.001），硬脂酸（C18：0， P <0.001），油酸（C18：1， P <0.001）和MUFA（ P <0.001）。 FASN ， SCD 和 SREBP1 基因的多态性对任何肉类产量没有影响。脂肪酸合成涉及的三个基因（ FASN ， SCD 和 SREBP1 ）对脂肪酸组成没有明显的上位性影响。在任何i体性状的 FASN 和 SCD 之间均未检测到上位性相互作用（ P ， SCD 和 GHL127V ）的基因型从效果较小的等位基因替换为效果较大的等位基因时， C18：1的百分比增长了4.46％。这三个遗传标记可解释C18：1水平超过20％的遗传变异。目前的研究结果表明，两个脂肪酸合成基因（ FASN 和 SCD ）的多态性独立地影响了长背心人胸肌的脂肪酸组成。这些结果表明， FASN 和 SCD 基因中的SNP是改善日本黑牛中脂肪酸组成的有用标记。

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