Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population

Ma Jingsong; Xiao Hai; Yang Yanjie; Cao Depin; Wang Lin; Yang Xiuxian; Qiu Xiaohui; Qiao Zhengxue; Song Junyao; Liu Yuexi; Wang Peng; Zhou Jiawei; Zhu Xiongzhao

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Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population

机译：色氨酸羟化酶2基因与生活事件的相互作用对中国汉族人群严重抑郁的敏感性

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Background: Major depression (MD) results from a complex synergy between genetic and environmental factors. The aim of this study is to analyze the interaction of tryptophan hydroxylase 2 gene (TPH2) variation and negative life events in the pathogenesis of MD. Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs11178997), and 1463G/A (rs120074175), were selected based on previous findings of associations with MD.

机译：背景：严重抑郁症（MD）是由遗传和环境因素之间的复杂协同作用导致的。这项研究的目的是分析色氨酸羟化酶2基因（TPH2）变异与MD发病机理中的负性生活事件的相互作用。基于与MD关联的先前发现，选择了三个TPH2多态性-703G / T（rs4570625），-473T / A（rs11178997）和1463G / A（rs120074175）。

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《Journal of affective disorders》 |2015年第null期|共6页
作者
Ma Jingsong; Xiao Hai; Yang Yanjie; Cao Depin; Wang Lin; Yang Xiuxian; Qiu Xiaohui; Qiao Zhengxue; Song Junyao; Liu Yuexi; Wang Peng; Zhou Jiawei; Zhu Xiongzhao;
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正文语种 eng
中图分类医学心理学、病理心理学;
关键词
Tryptophan hydroxylase 2 gene; Major depression; Gene-environment interaction; Negative life events;

机译：色氨酸羟化酶2基因;严重抑郁;基因-环境相互作用;负性生活事件;

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1. Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population [J] . Ma Jingsong, Xiao Hai, Yang Yanjie, Journal of affective disorders . 2015,第Null期

机译：色氨酸羟化酶2基因与生活事件的相互作用对中国汉族人群严重抑郁的敏感性
2. The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population. [J] . Sun N, Xu Y, Wang Y, Journal of neural transmission . 2008,第12期

机译：去甲肾上腺素转运蛋白基因与阴性生活事件在中国汉族人群中的联合作用。
3. The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population [J] . Ning Sun, Yong Xu, Yanfang Wang, Journal of Neural Transmission . 2008,第12期

机译：去甲肾上腺素转运蛋白基因与阴性生活事件在中国汉族人群中的联合作用
4. Association study of IL-17RC, CHL1,DSCAM and CNTNAP2 genes polymorphisms with adolescent idiopathic scoliosis susceptibility in a Chinese Han population [C] . Song ZHOU, Zezhang ZHU, Xusheng QIU, International Research Society of Spinal Deformities . 2012

机译：IL-17RC，CHL1，DSCAM和CNTNAP2基因多态性研究中国汉族人群青少年特发性脊柱缺损性研究
5. Personality, stressful life events, and treatment response in Major Depression. [D] . Bulmash, Eric Lewis. 2007

机译：重性抑郁症中的人格，压力性生活事件和治疗反应。
6. GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population [O] . Jingsong Ma, Lin Wang, Yanjie Yang, -1

机译：GNB3和CREB1基因多态性与不良生活事件相结合增加了中国汉族人群严重抑郁的易感性
7. GNB3 and CREB1 gene polymorphisms combined with negative life events increase susceptibility to major depression in a Chinese Han population. [O] . Jingsong Ma, Lin Wang, Yanjie Yang, 2017

机译：GNB3和CREB1基因多态性与负性生活事件相结合，增加了中国汉族人群对抑郁症的易感性。

Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population

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