A newly modified prefilled syringe to prevent plunger/piston misassembly.

摘要

Prefilled syringes are intended to be used as a strategy to minimize errors in the administration of potent cardiovascular drugs and to provide rapid access for critically ill patients [1]. We previously reported a case of dopamine leakage from a Prefilled Inovan injection 0.3 % syringe (marketed by Kyowa Hakko Kirin, Tokyo, Japan; manufactured by Terumo, Tokyo, Japan) caused by plunger/ piston misassembly [2]. In the conventional assembly, the rigid plunger head is molded with a small number of male threads, and the cylindrical wall of the elastic rubber piston is thin (Fig. la). When the male screw thread molded at the top end of the plunger could not engage entirely with the female screw thread molded on the inside wall of the rubber piston, the cylindrical rubber wall of the piston gradually became partially contorted as pressure was applied to the plunger after continuous infusion was started, possibly leading to erratic drag delivery (personal communication from Terumo Corporation [2]).