首页> 外文期刊>Journal of Andrology >Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone.
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Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone.

机译:饮食和运动加上经皮睾丸激素治疗的五十二周治疗可逆转代谢综合征,并改善初诊2型糖尿病和血浆睾丸激素水平异常的男性的血糖控制。

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Men with the metabolic syndrome (MetS) and type 2 diabetes (T2D) often have low testosterone levels. Elevating low testosterone levels may improve features of the MetS and glycemic control. In a single blind, 52-week randomized clinical trial, the effects of supervised diet and exercise (D&E) with or without transdermal testosterone administration on components of the MetS in hypogonadal men with the MetS and newly diagnosed T2D were assessed. A total of 32 hypogonadal men (total testosterone <12.0 nmol/L) with newly diagnosed T2D and with the MetS as defined by the Adult Treatment Panel III and the International Diabetes Federation received supervised D&E, but 16 received it in combination with testosterone gel (50 mg) once daily (n = 16). No glucose-lowering agents were administered prior to or during the study period. Outcome measures were components of the MetS as defined by the Adult Treatment Panel III and the International Diabetes Federation. Serum testosterone, glycosylated hemoglobin (HbA(1c)), fasting plasma glucose, high-density lipoprotein cholesterol, triglyceride concentrations, and the waist circumference improved in both treatment groups after 52 weeks of treatment. Addition of testosterone significantly further improved these measures compared with D&E alone. All D&E plus testosterone patients reached the HbA(1c) goal of less than 7.0%; 87.5% of them reached an HbA(1c) of less than 6.5%. Based on Adult Treatment Panel III guidelines, 81.3% of the patients randomized to D&E plus testosterone no longer matched the criteria of the MetS, whereas 31.3% of the D&E alone participants did. Additionally, testosterone treatment improved insulin sensitivity, adiponectin, and high-sensitivity C-reactive protein. Addition of testosterone to supervised D&E results in greater therapeutic improvements of glycemic control and reverses the MetS after 52 weeks of treatment in hypogonadal patients with the MetS and newly diagnosed T2D.
机译:患有代谢综合征(MetS)和2型糖尿病(T2D)的男性通常睾丸激素水平较低。升高低睾丸激素水平可以改善MetS和血糖控制的功能。在一项单盲,为期52周的随机临床试验中,评估了有或没有经皮睾丸激素的有监督饮食和运动(D&E)对患有MetS和新诊断为T2D的性腺功能减退男性患者MetS成分的影响。共有32例性腺功能减退的男性(总睾丸激素<12.0 nmol / L)被新诊断为T2D并具有成人治疗小组III和国际糖尿病联合会定义的MetS,接受了D&E的监督,但16例接受了睾丸激素凝胶联合治疗( 50 mg)每天一次(n = 16)。在研究期间或之前未给予降糖药。结果措施是成人治疗小组III和国际糖尿病联盟定义的MetS的组成部分。在52周的治疗后,两个治疗组的血清睾丸激素,糖基化血红蛋白(HbA(1c)),空腹血糖,高密度脂蛋白胆固醇,甘油三酸酯浓度和腰围均得到改善。与单独的D&E相比,添加睾丸激素可显着改善这些措施。所有D&E加睾丸激素患者的HbA(1c)目标均低于7.0%;其中87.5%的HbA(1c)低于6.5%。根据成人治疗小组III指南,随机分配到D&E加睾丸激素的患者中有81.3%不再符合MetS的标准,而仅D&E参与者中有31.3%的患者符合。此外,睾丸激素治疗可改善胰岛素敏感性,脂联素和高敏感性C反应蛋白。在性腺功能减退的MetS和新诊断为T2D的患者中,在52周的治疗后,将睾丸激素添加到有监督的D&E中可改善血糖控制的治疗效果,并逆转MetS。

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