Activating PPAR alpha Prevents Post-Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts

摘要

Rationale: Post-ischemic contractile dysfunction is a contributor to morbidity and mortality after the surgical correction of congenital heart defects in neonatal patients. Pre-existing hypertrophy in the newborn heart can exacerbate these ischemic injuries, which may partly be due to a decreased energy supply to the heart resulting from low fatty acid -oxidation rates.