Preparation and Evaluation of Surface Modified Lactose Particles for Improved Performance of Fluticasone Propionate Dry Powder Inhaler

Singh Deepak J.; Jain Rajesh R.; Soni P. S.; Abdul Samad; Darshana Hegde; Gaikwad Rajiv V.; Menon Mala D.

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Preparation and Evaluation of Surface Modified Lactose Particles for Improved Performance of Fluticasone Propionate Dry Powder Inhaler

机译：用于改善丙酸氟替卡松干粉吸入器性能的表面改性乳糖颗粒的制备和评价

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Background: Dry powder inhalers (DPI) are generally formulated by mixing micronized drug particles with coarse lactose carrier particles to assist powder handling during the manufacturing and powder aerosol delivery during patient use.

机译：背景：干粉吸入器（DPI）通常是通过将微粉化的药物颗粒与粗乳糖载体颗粒混合来配制的，以在制造过程中协助粉末处理以及在患者使用过程中协助粉末气雾剂的输送。

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来源
《Journal of aerosol medicine and pulmonary drug delivery》 |2015年第4期|共14页
作者
Singh Deepak J.; Jain Rajesh R.; Soni P. S.; Abdul Samad; Darshana Hegde; Gaikwad Rajiv V.; Menon Mala D.;
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正文语种 eng
中图分类药学;
关键词
dry powder inhaler; Fluticasone propionate; force control agents; surface modified lactose;

机译：干粉吸入器;丙酸氟替卡松;力控制剂;表面改性乳糖;

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1. Preparation and Evaluation of Surface Modified Lactose Particles for Improved Performance of Fluticasone Propionate Dry Powder Inhaler [J] . Singh Deepak J., Jain Rajesh R., Soni P. S., Journal of aerosol medicine and pulmonary drug delivery . 2015,第4期

机译：用于改善丙酸氟替卡松干粉吸入器性能的表面改性乳糖颗粒的制备和评价
2. Probing the influence of lactose fines, a USP modified induction port and modified DDU apparatus on the aerodynamic behavior of a fluticasone propionate dry powder inhaler [J] . Mehta Piyush, Bothiraja C., Kadam Shivajirao, New Journal of Chemistry . 2019,第44期

机译：乳糖细粒，USP改性诱导端口和改性DDU装置对氟酮丙酸酯干粉吸入器的空气动力学行为的影响
3. Randomized, double-blind trial evaluating the efficacy and safety of fluticasone propionate and fluticasone propionate/salmeterol delivered via multidose dry powder inhalers in patients with persistent asthma aged 12 years and older [J] . Raphael Gordon, Yiu Gloria, Sakov Anat, The journal of asthma . 2018,第6期

机译：通过多糖干粉吸入器持续12岁及以上的患者通过多阶干粉吸入剂递送氟酮丙酸酯和氟替卡松丙酸盐/盐摩尔的疗效和安全性的随机性，双盲试验
4. THE EFFECT OF CARRIER PARTICLE SIZE ON ADHESION, CONTENT UNIFORMITY AND INHALATION PERFORMANCE OF BUDESONIDE USING DRY POWDER INHALERS [C] . W. Kaialy, H. Larhrib, A. Nokhodchi UK-China Particle Technology Forum . 2012

机译：使用干粉吸入器对载体粒径对粘附，含量均匀性和吸入性能的影响
5. Effects of particle surface modifications on dry powder formulation performances. [D] . Schueller, Laurent Bruno. 2005

机译：颗粒表面改性对干粉配方性能的影响。
6. Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling [O] . Xiang Kou, Lai Wah Chan, Changquan Calvin Sun, 2017

机译：气流粉碎制备干粉吸入器用平板状乳糖载体颗粒
7. Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling [O] . Xiang Kou, Lai Wah Chan, Changquan Calvin Sun, 2017

机译：用空气喷射研磨法制备用于干粉吸入器的板状乳糖载体颗粒

Preparation and Evaluation of Surface Modified Lactose Particles for Improved Performance of Fluticasone Propionate Dry Powder Inhaler

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