Preparing Fresh Tissues for the Microscope

摘要

IN 1905, JAMA PUBLISHED A BRIEF REPORT AUTHORED BY Mayo Clinic pathologist and bacteriologist Louis B. Wilson in which he outlined a method whereby fresh tissue removed during surgery was examined immediately for diagnosis by microscopy. This was not the first exposition of the rapid preparation of fresh tissues for microscopy, but Wilson's refinements allowed the method to be applied to every surgical specimen removed at Mayo Clinic. This operational change for surgeons and pathologists heralded the beginning of the "frozen section" and, in turn, what is known today as "surgical pathology," a subspecialty discipline within the broader context of postmortem pathology