The Importance of Biodiversity to Medicine

摘要

Natural products compose a superb resource for drug discovery because they have evolved, in some cases during millions of years, to exploit fundamental biological pathways often shared by humans. In addition, the random aspect of the evolutionary process gives rise to products with unforeseen, and perhaps unforeseeable, biological actions, allowing for the development of pharmaceuticals with novel mechanisms of action. For example, paclitaxel (discovered in the bark of the Pacific yew tree), a mainstay of chemotherapy for a variety of cancers, was the first drug shown to inhibit microtubule breakdown during mitosis.