Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway

Yang Ke; Wang Xiaoqun; Liu Zhuhui; Lu Lin; Mao Jinyan; Meng Hua; Wang Yanan; Hu Yong; Zeng Ying; Zhang Xiaojie; Chen Qiujing; Liu Yan; Shen Weifeng

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Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway

机译：氧化的低密度脂蛋白促进通过Toll样受体4-Src途径的巨噬细胞脂质积累。

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Background: Uptake of oxidized low-density lipoprotein (oxLDL) by macrophages is recognized as a crucial step in the development of atherosclerosis, whereas the precise molecular mechanisms involving it remain to be elucidated.

机译：背景：巨噬细胞摄取氧化的低密度脂蛋白（oxLDL）被认为是动脉粥样硬化发展的关键步骤，而涉及它的确切分子机制尚待阐明。

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来源
《Circulation journal》 |2015年第11期|共11页
作者
Yang Ke; Wang Xiaoqun; Liu Zhuhui; Lu Lin; Mao Jinyan; Meng Hua; Wang Yanan; Hu Yong; Zeng Ying; Zhang Xiaojie; Chen Qiujing; Liu Yan; Shen Weifeng;
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正文语种 eng
中图分类心脏、血管（循环系）疾病;
关键词
Atherosclerosis; Lipid; Macrophage; Src; Toll-like receptor 4 (TLR4);

机译：动脉粥样硬化;脂质;巨噬细胞;Src;Toll样受体4（TLR4）;

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1. Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway [J] . Yang Ke, Wang Xiaoqun, Liu Zhuhui, Circulation journal . 2015,第11期

机译：氧化的低密度脂蛋白促进通过Toll样受体4-Src途径的巨噬细胞脂质积累。
2. MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. [J] . Yang K, He YS, Wang XQ, FEBS letters. . 2011,第6期

机译：MiR-146a通过靶向toll样受体4抑制氧化的低密度脂蛋白诱导的脂质蓄积和炎症反应。
3. PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor ?oB Pathway [J] . Caihong Liang, Xiaochen Wang, Jianping Hu, Cellular Physiology and Biochemistry . 2017,第2期

机译：PTPRO通过类似Toll受体4 /核因子？oB途径促进氧化的低密度脂蛋白诱导的氧化应激和细胞凋亡。
4. Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1) in Adenosine Diphosphate-Activated Platelet Adhesion to Human Brain Microvascular Endothelial Cells Under Flow In Vitro [C] . Norio Tanahashi, Yoshiaki ItohMIideki Satoh, Takato Abe, Keio International Symposia for Life Sciences and Medicine . 2005

机译：凝集素样氧化低密度脂蛋白受体-1（LOX-1）在体外流量下对人脑微血管内皮细胞的腺苷二磷酸活性血小板粘附的作用
5. Multifunctional polymers for inhibition of oxidized lipoprotein accumulation and inflammation in macrophage cells. [D] . Iverson, Nicole M. 2010

机译：用于抑制巨噬细胞中氧化脂蛋白积聚和炎症的多功能聚合物。
6. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells [O] . David A. Bird, Kristin L. Gillotte, Sohvi Hörkkö, 1999

机译：诱发的小鼠腹膜巨噬细胞上氧化型低密度脂蛋白的受体可以识别修饰的脂质部分和修饰的蛋白质部分：与凋亡细胞的巨噬细胞识别有关
7. Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway [O] . Ke Yang, Xiaoqun Wang, Zhuhui Liu, 2015

机译：氧化低密度脂蛋白通过Toll样受体4-SRC途径促进巨噬细胞脂质积累

Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway

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