Effect of infliximab on male fertility: Comment on the article 'Fertility in male patients with seronegative spondyloarthropathies treated with infliximab' by Saougou et al., Joint Bone Spine 2013;80, 34-37

摘要

We read with interest the article by Saougou and others in this journal [1] and would like to add our note of caution. In addition to their article, little data has addressed the issue of male fertility on anti-TNF therapy. Villiger and colleagues [2] suggested that sperm quality of patients with spondyloarthritis receiving long term anti-TNF inhibition therapy was comparable to that in healthy controls and imputed reassurance for male patients treated with anti-TNF therapy for fatherhood. We report herein one of our ankylosing spondylitis (AS) patients whose sperm count decreased precipitously while treated with infliximab, correlating with infertility while under treatment.