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首页> 外文期刊>Japanese Journal of Pharmacology >Expression of cyclooxygenase mRNA in the livers of mice with interferon-gamma chronic hepatitis.
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Expression of cyclooxygenase mRNA in the livers of mice with interferon-gamma chronic hepatitis.

机译:γ-干扰素慢性肝炎小鼠肝脏中环氧合酶mRNA的表达。

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摘要

Interferon-gamma (IFN-gamma) transgenic mice expressed the IFN-gamma gene in the liver and developed chronic hepatitis. The expression of cyclooxygenase (Cox)-1 and -2 mRNA were studied in the livers of these mice. A faint band of Cox-1 mRNA was observed in the livers of both normal and transgenic mice. Slight expression of Cox-2 mRNA was observed in the normal mouse liver, and this mRNA expression was induced in the transgenic mouse liver. The present results showed the induction of Cox-2 mRNA expression in the livers of transgenic mice with chronic hepatitis.
机译:干扰素-γ(IFN-γ)转基因小鼠在肝脏中表达IFN-γ基因,并发展为慢性肝炎。在这些小鼠的肝脏中研究了环氧合酶(Cox)-1和-2 mRNA的表达。在正常和转基因小鼠的肝脏中均观察到淡淡的Cox-1 mRNA带。在正常小鼠肝脏中观察到Cox-2 mRNA的少量表达,并且在转基因小鼠肝脏中诱导了该mRNA的表达。目前的结果表明,在慢性肝炎转基因小鼠的肝脏中,Cox-2 mRNA的表达被诱导。

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