Synthesis and characterization of N-glucosylated dithiadiazepine derivatives through carbon-sulfur bond formation

摘要

New 4,7-bis(arylamino)-2-tetra-O-acetyl-beta-D-glucopyranosylimino-1,3,5,6-dithiadiazepines were synthesized via reaction of N-tetra-O-acetyl-beta-D-glucopyranosyl isocyanodichloride with 1,6-diaryl-2,5-dithio-bis-ureas without using any catalyst. Thus, the synthesis of 7-membered heterocycles containing two sulfur and two nitrogen atoms through carbon-sulfur bond formation was explored. The chemical structures of these new compounds were elucidated by IR, H-1 NMR, C-13 NMR, mass spectral, and elemental analyses.