A Modified Procedure for the Synthesis of 5-Amino-3-Arylisoxazoles and Their Reactions With Tetrasulfur Tetranitride Antimony(v) Chloride Complex (S_4N_4 centre dot SbCl_5):Novel Synthesis of 3-aRYL-1,2,5-Thiadiazole-4-Carboxamides

摘要

Dropwise adition of #alpha3-bromo ketoximes ot a solution of KCN in MeOH at room temperature gave 5-amino-3-arylisoxazoles in moderate to good yields.Treatment of the isoxazoles prepared with tetrasulfur tetranitride antimony (V) chloride complex (S_4N_4 centre dot SbCl_5) in toluene at 100degC afforded novel 3-aryl-1,2,5-thiadiazole-4-carboxamides.