Reaction of 3,4-dithio-toluene with 4-benzylidene-2-phenyloxazol-5(4H)-one give benzodithian 3-one derivative

摘要

Unsaturated oxazol-5(4H)-ones constitute an important class of synthon. In this paper we present our findings on the reaction of 4-benzylidene-2-phenyloxazol-5(4H)-one and 4-cyclohexylidene-2-phenyloxazol-5(4H)-one and 4-cyclohexylidene-2-phenyloxazol-5(4H)-one with 3,4-dithio-toluene in the presence of triethylamine. The intermediates can be isolated under nautral conditions. Base mediated reaction of 3,4-dithio toluene with 4-benzylidene-2-phenyloxazol-5(4H)-one in boiling benzene was unsuccessful but simple heating of these reactants at an elevated temperature give 2-benzamido-2-cyclohexyl-7-methyl-l,4-benzodithian-3-one.