CONVENIENT SYNTHESIS OF 6-AMINO-3,4-DIHYDRO-2H-PYRIMIDO[2,1-a]ISOQUINOLINE-7-CARBONITRILES AND 5-AMINO-2,3-DIHYDROIMIDAZO[2,1-a]ISOQUINOLINE-6-CARBONITRILES

摘要

An efficient method for the preparation of 6-arnino-3,4-dihydro-2H-pyrimido[2,1-a]isoquinoline-7-carbonitriles and 5-amino-2,3-dihydroimidazo[2,1-a]isoquinoline-6-carbonitriles by the copper(I) iodide catalyzed reaction of 2-(2-bromophenyl)-1,4,5,6-tetrahydropyrimidines and 2-(2-bromophenyl)-4,5-dihydro-3H-imidazoles, respectively, with 1,3-propanedinitrile (malononitrile) in DMSO in the presence of excess potassium carbonate has been developed.