SYNTHESIS, CHARACTERIZATION AND SUPPRESSION OF IMPURITIES DURING OPTIMIZATION OF DABIGATRAN ETEXILATE

摘要

The synthetic methods for two impurities of dabigatran etexilate are firstly described, and both of two impurities are characterized by NMR and MS spectral data. The suppression of impurities as well as the optimization process of dabigatran etexilate is also disclosed.