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Synthesis And Comparison Of Biological Activities Of Azetidinone, Thiazolidinone And Related Compounds

机译:氮杂环丁酮,噻唑烷酮及相关化合物的生物活性的合成与比较

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Recent discoveries of non-classical β-lactam antibiotics such as nocardicines, monobactams and thienamycin have stimulated much interest. Besides this, the unique feature of these strained molecules is that these heterocycles are becoming powerful building blocks for the synthesis of a variety of organic compounds. During the present work, azetidinone and thiazolidinone derivatives of 3-chloro, 4-fluoro aniline and 4-chloro aniline were prepared. The synthesis was further extended for deriving arylidene derivatives from the thiazolidinones.
机译:非经典的β-内酰胺类抗生素(如诺卡曲霉素,单bactams和硫霉素)的最新发现引起了人们的极大兴趣。除此之外,这些应变分子的独特特征是这些杂环正成为合成各种有机化合物的强大构建基块。在本工作中,制备了3-氯,4-氟苯胺和4-氯苯胺的氮杂环丁酮和噻唑烷酮衍生物。该合成进一步扩展为从噻唑烷酮衍生出亚芳基衍生物。

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