A novel and efficient method for the synthesis of β-triazolylalkenes via the phase transfer catalyzed wittig reaction

摘要

N-Alkylation of phosphonium salt 1 with 1H-1,2,4-triazole gave γ-triazolylpropyltriphenylphosphonium bromide 2, which reacted with aromatic aldehydes 3 under the phase transfer conditions ot afford β-triazolylalkenes 4. The synthesis and biological activity of azole compounds have received continuing attention in the last three decades~1. Many N-vinyl azoles were found to be effective fungicides and plant growth regulators, such as diniconazole (S-3308) and uniconazole (S-3307). As part of an ongoing programme and interest in the ylide chemistry and biologically active compounds~2, here we wish to report a novel and efficient method for the synthesis of β-triazolylalkenes via the phase transfer catalyzed Wittig reaction.