The utilization of 2-aminoprop-1-ene-1,1,3-tricarbonitrile as a precursor to quinoline, furan and thiophene derivatives with antitumor activities

摘要

The condensation reaction of 2-aminoprop-1-ene-1,1,3- tricarbonitrile (1) with 2-acetyl-furan (2) afforded 2-amino4-(furan-2-yl)penta-1,3-diene-1,1,3-tricarbonitrile (3). The latter compound underwent a series of heterocyclization reactions to give quinoline, furan, pyrazole and thiophene derivatives. The antitumor evaluation of the newly synthe-sized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Three of the synthesized compounds, namely 4, 5d and 12 showed high inhibitory effects.