Dynamic characteristics of MR diffusion-weighted imaging in a rabbit liver VX-2 tumor model.

摘要

To investigate prospectively dynamic characteristics of the apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) in a rabbit VX-2 tumor model.Forty New Zealand rabbits were included in the study, and 47 rabbit VX-2 tumor models were developed by direct and intrahepatic implantation after opening the abdominal cavities. DWI was carried out periodically and respectively on days 7, 14 and 21 after implantation. The VX-2 tumor samples were studied by pathology. The distinction of VX-2 tumors on DWI was assessed by their ADC values by analysis of variance (ANOVA) using SPSS12.0 software.The ADC values (mean?±?SD)?×?10(-3)?mm(2)/s of 47 VX-2 tumors in the peripheral and central areas were 2.18?±?0.29, 1.96?±?0.33, 1.80?±?0.35, 2.20?±?0.29, 2.05?±?0.30 and 1.96?±?0.48, respectively, on days 7, 14 and 21 after implantation. ADC values of 47 VX-2 tumors in the area of the tumor periphery, center and normal parenchyma were higher when the b-value was 100?s/mm(2) than those when the b-value was 300?s/mm(2) (F?=?17.964, p?