MICROWAVE-ASSISTED SYNTHESIS OF 2-SUBSTITUTED 1H-BENZO[d]IMIDAZOLES AND THEIR ANTIFUNGAL ACTIVITIES IN VITRO

摘要

An efficient and novel microwave-assisted synthesis of 1H-benzo[b]imidazole derivatives via nitriles and o-phenyldiamines in the presence of polyphosphoric acid (PPA) and phosphoric acid is described. This method provides several advantages such as commercially high availabilities of starting materials, short reaction times, high yields and a simple workup procedure. Systematically antifungal biological tests showed 3f was most promising candidate against six phytopathogenic fungi.