SYNTHESIS OF HUMAN MILK OLIGOSACCHARIDES: 2'- AND 3-FUCOSYLLACTOSE

摘要

The human milk oligosaccharides 2'-fucosyllactose and 3-fucosyllactose were synthesized using a selectively protected 1-O-allyllactosyl acceptor and a 1-O-trichloroacetimidate fucosyl donor. This synthesis utilized fewer toxic reagents and milder reaction conditions as compared to previous syntheses.