EFFICIENT ORGANOCATALYTIC MICHAEL ADDITION REACTION OF β-KETOESTERS UNDER HIGH PRESSURE

摘要

The Michael addition reaction of β-ketoesters was efficiently promoted by a cooperative dual catalyst system composed by DMAP and thiourea A under high-pressure conditions (0.8 GPa) in toluene. The expected relatively congested adducts of 1,5-dicarbonyl compounds were prepared in high to excellent yield.