CYTOTOXIC XANTHONES FROM HYPERICUM CHINENSE

摘要

-Two new xanthones, l-hydroxy-4-(2-hydroxyethyl)-3,8-dimethoxy-9H-xanthen-9-one (1) and (5)-l-hydroxy-4-(l-hydroxy-3-oxobutyl)-3,8-dimethoxy-9H-xanthen-9-one (2), together with three known xanthones (3-5) were isolated from the leaves and stems of Hypericum chinense. Their structures were elucidated by spectroscopic methods, including extensive ID-and 2D NMR techniques. Compounds 1-5 were tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). The results revealed that compound 1 showed high cytotoxicity against A549 and PC3 cell with IC_(50) values of 2.8 and 3.4 μM, and 2 showed high cytotoxicity against PC3 cell with IC50 valve of 2.8 μM, respectively.