SYNTHESIS AND BIOLOGICAL EVALUATIONS OF A SERIES OF NOVEL AZOLYL, AZINYL, PYRANYL, CHROMONYL AND AZEPINYL PHOSPHONATES

摘要

-A facile synthetic methodology of novel azolyl, azinyl and azepinyl phosphonates as cyclic a-aminophosphonates was described. Chromonyl α-aminophosphonates, γ-pyranyl and y-pyridinyl phosphonates were also prepared. The methodology depends on reaction of 6-methyl-3-formylchromone, nitrogen and carbon nucleophiles in the presence of diethyl phosphite in one-pot three-components under solvent-free conditions. The products were evaluated for their antimicrobial activities and antioxidant properties.