SYNTHESIS OF 1-AMINO-1-ARYL-1,2-DIHYDROPYRROLO[3,4-c]-PYRIDIN-3-ONE DERIVATIVES BY THE REACTION OF 4-LITHIOPYRIDINE-3-CARBONITRILE WITH AROMATIC TERTIARY AMIDES

摘要

A one-pot procedure for the preparation of I-amino-1-aryl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one derivatives from pyridine-3-carbonitrile and aromatic tertiary amides has been developed. Thus, the reaction of 4-lithiopyridine-3-carbonitriIe, generated by the treatment of pyridine-3-carbonitrile with lithium 2,2,6,6-tetramethylpiperidide (LTMP), with aromatic tertiary amides in THE at-78 °C yields the pyrrolopyridinone derivatives in moderate yields.